Cat. No. 3634
Chemical Name: 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin
Biological ActivitySelective positive allosteric modulator of M5 receptors (EC50 values are 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively). Displays no activity at M2 and M4 receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bridges et al (2009) Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J.Med.Chem. 52 3445. PMID: 19438238.
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Keywords: VU 0238429, supplier, Selective, positive, allosteric, modulators, PAMs, M5, receptors, Muscarinic, Acetylcholine, Ach, VU0238429
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