R&D Systems Inc. Tocris Bioscience Boston Biochem

VU 0238429

Cat. No. 3634

VU 0238429 C17H12F3NO4 [1160247-92-6]

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Chemical Name: 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin

Biological Activity

Selective positive allosteric modulator of M5 receptors (EC50 values are 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively). Displays no activity at M2 and M4 receptors.

Technical Data

M.Wt:
351.28
Formula:
C17H12F3NO4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1160247-92-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Bridges et al (2009) Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J.Med.Chem. 52 3445. PMID: 19438238.

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View Related Products by Target

Keywords: VU 0238429, supplier, Selective, positive, allosteric, modulators, PAMs, M5, receptors, Muscarinic, Acetylcholine, Ach, VU0238429

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