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VU 0238429

Cat No. 3634

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Chemical Name: 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin

Biological Activity

Selective positive allosteric modulator of M₅ receptors (EC₅₀ values are 1.16, >30 and >30 μM at M₅, M₁ and M₃ receptors respectively). Displays no activity at M₂ and M₄ receptors.

Technical Data

M.Wt:

351.28

Formula:

C₁₇H₁₂F₃NO₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Bridges et al (2009) Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J.Med.Chem. 52 3445.

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Acetylcholine Muscarinic Receptors

Keywords: VU 0238429, Selective, positive, allosteric, modulators, M5, receptors, Muscarinic, Acetylcholine, Ach

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