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Cyclosporin A

Cat. No. 1101

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Alternative Name: Ciclosporin A

Biological Activity

Immunosuppressant; inhibits phosphatase activity of calcineurin (IC₅₀ = 5 nM). Also inhibits formation and opening of the mitochondrial permeability transition pore (MPTP).

Technical Data

M.Wt:

1202.63

Formula:

C₆₂H₁₁₁N₁₁O₁₂

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Desiccate at -20°C

CAS No:

59865-13-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 2821.

Fruman et al (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc.Natl.Acad.Sci.U.S.A. 89 3686. PMID: 1373887.

Brookemeier and Pfeiffer (1995) Inhibition of the mitochondrial permeability transition pore by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases. Biochemistry 34 16440. PMID: 8845372.

Nakata et al (1998) Evidence that cyclosporin A and dexamethasone inhibit allergic airway inflammation via suppression of interleukin-5 synthesis by T cells. Br.J.Pharmacol. 124 1425. PMID: 9723954.

Hojo et al (1999) Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature 397 530. PMID: 10028970.

If you know of a relevant citation for this product please let us know.

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Keywords: Cyclosporin A, supplier, Calcineurin, inhibitors, Protein, Ser/Thr, Phosphatases, CyclosporinA, immunosuppressant, CsA, inhibits, mPTP, mitochondrial, permeability, transition, pore, antibiotics

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