R&D Systems Inc. Tocris Bioscience Boston Biochem

SID 26681509

Cat. No. 3625

SID 26681509 C27H33N5O5S [958772-66-2]

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Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide

Biological Activity

Potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.

Technical Data

M.Wt:
539.65
Formula:
C27H33N5O5S
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
958772-66-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Myers et al (2008) Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg.Med.Chem.Lett. 18 210. PMID: 18060772.

Shah et al (2008) Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Mol.Pharmacol. 74 34. PMID: 18403718.

If you know of a relevant citation for this product please let us know.

Keywords: SID 26681509, supplier, SID26681509, cathepsin, L, inhibitor, inhibits, cysteine, protease, antimalarial

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