SID 26681509

Cat. No. 3625

SID 26681509 C27H33N5O5S [958772-66-2]

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Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide

Biological Activity

Potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.

Technical Data

Soluble to 50 mM in DMSO and to 10 mM in ethanol
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Myers et al (2008) Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg.Med.Chem.Lett. 18 210. PMID: 18060772.

Shah et al (2008) Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Mol.Pharmacol. 74 34. PMID: 18403718.

If you know of a relevant citation for this product please let us know.

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Keywords: SID 26681509, supplier, SID26681509, cathepsin, L, inhibitor, inhibits, cysteine, protease, antimalarial, Cathepsin Inhibitors

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