Cat. No. 3616
Chemical Name: (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-benzopyrano[3,4-b]furo[2,3-h]benzopyran-6(6aH)-one
Biological ActivityMitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 μM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Cherednichenko et al (2004) NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circ.Res. 94 478. PMID: 14699012.
Uversky (2004) Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res. 318 225. PMID: 15258850.
Gomez et al (2007) Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front.Biosci. 12 1079. PMID: 17127363.
Mader et al (2012) Rotenone inhibits autophagic flux prior to inducing cell death. ACS Chem.Neurosci. 3 1063. PMID: 23259041.
If you know of a relevant citation for this product please let us know.
Keywords: Rotenone, supplier, inhibitors, complex, I, mitochondrial, electron, transport, chain, Oxidative, phosphorylation
Find multiple products by catalog number
New Products in this Area
Irreversible mitochondrial respiratory complex II inhibitorCapecitabine
Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis8-Chloroadenosine
Cytotoxic nucleoside analog; inhibits RNA synthesis
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.