Home » Pharmacology » Ion Channels » Ligand-gated Ion Channels » GABA_A and GABA_C Receptors » GABA_A Receptors » Indiplon

Indiplon

Cat. No. 3597

Price and Availability

For Indiplon pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: NBI 34060

Chemical Name: N-Methyl-N-[3-[3-[2-thienylcarbonyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide

Biological Activity

Potent GABA_A receptor positive allosteric modulator that acts at the benzodiazepine site (K_i values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity for α1 subunit-containing receptors (EC₅₀ values are 2.6, 24, 60 and 77 nM for α1β2γ2, α2β2γ2, α3β3γ2 and α5β2γ2 receptors respectively). Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active.

Technical Data

M.Wt:

376.43

Formula:

C₂₀H₁₆N₄O₂S

Solubility:

Soluble to 50 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

325715-02-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Foster et al (2004) In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic. J.Pharmacol.Exp.Ther. 311 547. PMID: 15256538.

Sullivan et al (2004) Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABA_A receptor. J.Pharmacol.Exp.Ther. 311 537. PMID: 15256540.

Petroski et al (2006) Indiplon is a high-affinity positive allosteric modulator with selectivity for α1 subunit-containing GABA_A receptors. J.Pharmacol.Exp.Ther. 317 369. PMID: 16399882.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

GABA_A and GABA_C Receptors

GABA_A Receptors

Keywords: Indiplon, supplier, Subtype-selective, GABAA, receptor, positive, allosteric, modulators, Receptors, NBI34060

Quick Order

Find multiple products by catalog number

Pain Research Guide

Reserve your free copy

Highlights over 280 products for Pain research. Reserve copy

GABA Review

Written by Ian Martin, Norman Bowery & Susan Dunn. Request a copy or view PDF today.

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.

New Product Guide

Highlights over 130 new products added in 2012. Request a copy or view PDF today.

Tocris Events

Win a Kindle

11th Congress of the French Neuroscience Society

May 21 - 24, 2013

Lyon, France

Booth Number: 32