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Goserelin acetate

Cat No. 3592

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Biological Activity

Synthetic gonadotrophin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotrophin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.

Technical Data

M.Wt:

1269.42

C₅₉H₈₄N₁₈O₁₄

>98 %

Desiccate at -20°C

[145781-92-6]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Chrisp and Goa (1991) Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs 2 254. Dondi et al (1994) Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54 4091. Chatzaki et al (1996) The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 56 2059.

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