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GSK 650394

Cat. No. 3572

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Chemical Name: 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid

Biological Activity

Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC₅₀ values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC₅₀ ~ 1 μM).

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:

382.45

Formula:

C₂₅H₂₂N₂O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>97 %

Storage:

Store at RT

CAS No:

890842-28-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Sherk et al (2008) Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 68 7475. PMID: 18794135.

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