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Xanomeline oxalate

Cat No. 3569

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Chemical Name: 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahyd ro-1-methylpyridine oxalate

Biological Activity

Functionally selective muscarinic M₁ receptor agonist (EC₅₀ values are 0.3, 5, 42, 52 and 92.5 nM at M₁, M₃, M₅, M₄ and M₂ receptors respectively). Displays a complex pharmacological profile; reversible and wash-resistant binding resulting in full agonist activity at M₁, delayed wash-resistant partial agonist activity at M₂ and delayed wash-resistant full agonist activity at M₄. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.

Technical Data

M.Wt:

371.46

Formula:

C₁₄H₂₃N₃OS.C₂H₂O₄

Solubility:

Soluble to 10 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

[141064-23-5]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Stanhope et al (2001) The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat. J.Exp.Pharmacol.Ther. 299 782. Jakubik et al (2008) Importance and prospects for design of selective muscarinic agonists. Physiol.Res. 57 S39. Heinrich et al (2009) Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M₁-preferring receptor agonists. Eur.J.Pharmacol. 605 53.

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Keywords: Xanomeline oxalate, Functionally, selective, M1, agonists, Muscarinic, Receptors, Acetylcholine, ACh

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