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LU AA33810

Cat. No. 3562

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Chemical Name: N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide

Biological Activity

Potent neuropeptide Y (NPY) Y₅ receptor antagonist (K_i = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y₅ over Y₁, Y₂ and Y₄ receptors. Also binds human 5-HT_2B and 5-HT_1A receptors (K_i values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.

Technical Data

M.Wt:

423.62

Formula:

C₁₉H₂₅N₃O₂S₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

304008-29-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Walker et al (2009) The novel neuropeptide Y Y₅ receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress anxiety. J.Pharmacol.Exp.Ther. 328 900. PMID: 19098165.

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