R&D Systems Inc. Tocris Bioscience Boston Biochem

SDZ 220-581

Cat. No. 1250

SDZ 220-581 C16H17ClNO5P [174575-17-8]

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Chemical Name: (S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoic acid

Biological Activity

Competitive NMDA receptor antagonist (pKi = 7.7). Centrally active following oral administration (ED50 < 3.2 mg/kg for protection against MES-induced seizures).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M.Wt:
369.74
Formula:
C16H17ClNO5P
Solubility:
Soluble to 25 mM in DMSO with gentle warming and to 100 mM in 1.1eq. NaOH
Purity:
>98 %
Storage:
Store at RT
CAS No:
174575-17-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - I. Pharmacological characterization in vitro. Neuropharmacology 35 643. PMID: 8887974.

Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 35 655. PMID: 8887975.

Bakshi et al (1999) Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats. J.Pharmacol.Exp.Ther. 288 643. PMID: 9918570.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: SDZ 220-581, supplier, Competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, SDZ220-581

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