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KU 55933

Cat. No. 3544

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Special Conditions

No more than 50mg may be supplied to any one individual in any one year period.

If you require quantities greater than 50mg please click here and your request will be forwarded to KuDOS Pharmaceuticals.

Chemical Name: 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one

Biological Activity

Potent, selective and competitive ATM kinase inhibitor (K_i = 2.2 nM, IC₅₀ values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21^CIP1 levels in vitro. Acts as a radio- and chemosensitizer for the treatment of cancer.

Licensing Information

Sold for research purposes only under agreement from KUDOS

Technical Data

M.Wt:

395.49

Formula:

C₂₁H₁₇NO₃S₂

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>98 %

Storage:

Desiccate at -20°C

CAS No:

587871-26-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Hickson et al (2004) Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64 9152. PMID: 15604286.

Eaton et al (2007) Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J.Clin.Invest. 117 2723. PMID: 17786248.

Crescenzi et al (2008) Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy. Clin.Cancer Res. 14 1877. PMID: 18347191.

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Keywords: KU 55933, supplier, Potent, selective, ATM, kinase, inhibitors, Ataxia, Telangiectasia, Mutated, Kinase, Kinases, KU55933

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