Cat. No. 3541
Chemical Name: (R)-α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
Biological Activity5-lipoxygenase activating protein (FLAP) inhibitor. Inhibits the synthesis of leukotrienes B4 and C4 in animal models; inhibits synthesis of leukotriene B4 in A23187-stimulated leukocytes (IC50 values are 0.026, 0.039 and 0.22 μM for rat, mice and human leukocytes respectively). Displays anti-inflammatory activity. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Fruchtmann et al (1993) In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis. Agents Actions 38 188. PMID: 8213345.
Muller-Peddinghaus et al (1993) BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J.Pharmacol.Exp.Ther. 267 51. PMID: 8229782.
Hatzelmann et al (1994) Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions 43 64. PMID: 7741044.
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Keywords: BAY-X 1005, supplier, BAY-X1005, 5-lipoxygenase, activating, protein, FLAP, inhibitors, leukotriene, synthesis, signaling, signalling, inhibitors, antiinflammatory, 5-LOX