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BAY-X 1005

Cat. No. 3541

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Chemical Name: (R)-α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid

Biological Activity

5-lipoxygenase activating protein (FLAP) inhibitor. Inhibits the synthesis of leukotrienes B₄ and C₄ in animal models; inhibits synthesis of leukotriene B₄ in A23187-stimulated leukocytes (IC₅₀ values are 0.026, 0.039 and 0.22 μM for rat, mice and human leukocytes respectively). Displays anti-inflammatory activity. Orally active.

Technical Data

M.Wt:

361.43

Formula:

C₂₃H₂₃NO₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

128253-31-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Fruchtmann et al (1993) In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis. Agents Actions 38 188. PMID: 8213345.

Muller-Peddinghaus et al (1993) BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J.Pharmacol.Exp.Ther. 267 51. PMID: 8229782.

Hatzelmann et al (1994) Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions 43 64. PMID: 7741044.

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Keywords: BAY-X 1005, supplier, BAY-X1005, 5-lipoxygenase, activating, protein, FLAP, inhibitors, leukotriene, synthesis, signaling, signalling, inhibitors, antiinflammatory, 5-LOX