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HU 210

Cat. No. 0966

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Chemical Name: (6aR)-trans-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol

Biological Activity

A highly potent cannabinoid receptor agonist (K_i values are 0.061 and 0.52 nM at cloned human CB₁ and CB₂ receptors respectively). Induces spatial memory deficits and suppresses hippocampal firing rates in rats. Also displays agonist activity at GPR55 (EC₅₀ = 26 nM).

Technical Data

M.Wt:

386.57

Formula:

C₂₅H₃₈O₃

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

112830-95-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Mechoulam et al (1988) Enantiomeric cannabinoids: stereospecificity of psychotropic activity. Experientia 44 762. PMID: 3416993.

Howlett et al (1990) Stereochemical effects of 11-OH-Δ⁸-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor. Neuropharmacology 29 161. PMID: 2158635.

Robinson et al (2007) The synthetic cannabinoid HU210 reduces spatial memory deficits and suppresses hippocampal firing rates in rats. Br.J.Pharmacol. 151 688. PMID: 17502849.

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302.

If you know of a relevant citation for this product please let us know.

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