Cat. No. 3536
Biological ActivityPotent gonadotropin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.
(Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Beckers et al (1997) Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 251 17. PMID: 9300077.
Grundker and Emons (2003) Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 1 65. PMID: 14594454.
Telegdy et al (2009) Effects of the LHRH antagonist cetrorelix on the brain function in mice. Neuropeptides 43 229. PMID: 19375162.
If you know of a relevant citation for this product please let us know.
Keywords: Cetrorelix Acetate, supplier, Potent, GnRH, antagonists, Peptide, Receptors, Gonadotropin-releasing, Hormone, gonadotrophin
Find multiple products by catalog number
New Products in this Area
Oxytocin analogML 221
Apelin receptor (APJ) antagonistQ94 hydrochloride
Negative allosteric modulator at PAR1 receptorFSLLRY-NH2
PAR2 peptide antagonistSB 611812
Urotensin-II (UT) antagonist; attenuates cardiac dysfunctionTC-MCH 7c
Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonistCYM 9484
Potent NPY Y2 receptor antagonist
Win a Kindle
June 15 - 18, 2013
San Francisco, CA
Booth Number: 1032