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Cetrorelix Acetate

Cat. No. 3536

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Biological Activity

Potent gonadotropin-releasing hormone (GnRH) receptor antagonist (K_D = 0.202 nM, IC₅₀ = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.

Technical Data

M.Wt:

1491.11

Formula:

C₇₀H₉₂CIN₁₇O₁₄.C₂H₄O₂

Sequence:

XFASYXLRPA

(Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide)

Solubility:

Soluble in water

Storage:

Store at -20°C

CAS No:

120287-85-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Beckers et al (1997) Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 251 17. PMID: 9300077.

Grundker and Emons (2003) Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 1 65. PMID: 14594454.

Telegdy et al (2009) Effects of the LHRH antagonist cetrorelix on the brain function in mice. Neuropeptides 43 229. PMID: 19375162.

If you know of a relevant citation for this product please let us know.

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Keywords: Cetrorelix Acetate, supplier, Potent, GnRH, antagonists, Peptide, Receptors, Gonadotropin-releasing, Hormone, gonadotrophin

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7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy