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HQL 79

Cat No. 3530

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Chemical Name: 4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piper idine

Biological Activity

Orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC₅₀ = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.

Technical Data

M.Wt:

377.48

Formula:

C₂₂H₂₇N₅O

Solubility:

Soluble to 25 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

[162641-16-9]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Aritake et al (2006) Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J.Biol.Chem. 281 15277. Matsushita et al (1998) Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects. Jpn.J.Pharmacol. 78 11. Mohri et al (2006) Prostaglandin D₂-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J.Neurosci. 26 4383.

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