R&D Systems Inc. Tocris Bioscience Boston Biochem

Epothilone B

Cat. No. 3502

Epothilone B C27H41NO6S [152044-54-7]

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Alternative Name: Patupilone

Chemical Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Biological Activity

Microtubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest (EC50 = 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines in vitro, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50 values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice in vivo.

Technical Data

M.Wt:
507.68
Formula:
C27H41NO6S
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
152044-54-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Altmann et al (2000) Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim.Biophys.Acta 1470 M79. PMID: 10799747.

O'Reilly et al (2008) Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo. Cancer Chemother.Pharmacol. 62 1045. PMID: 18301895.

Narvi et al (2013) Altered TUBB3 expression contributes to the epothilone response of mitotic cells. Br.J.Cancer 108 82. PMID: 23321512.

If you know of a relevant citation for this product please let us know.

Keywords: Epothilone B, supplier, Microtubule, stabilization, agent, promotes, tubulin, polymerization, G2-M, cell, cycle, arrest, Tau, Tubulin, Mitosis, EpothiloneB

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