Epothilone B

Cat. No. 3502

Epothilone B C27H41NO6S [152044-54-7]

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Alternative Name: Patupilone

Chemical Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Biological Activity

Microtubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest (EC50 = 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines in vitro, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50 values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice in vivo.

Technical Data

M.Wt:
507.68
Formula:
C27H41NO6S
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
152044-54-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Altmann et al (2000) Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim.Biophys.Acta 1470 M79. PMID: 10799747.

O'Reilly et al (2008) Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo. Cancer Chemother.Pharmacol. 62 1045. PMID: 18301895.

Narvi et al (2013) Altered TUBB3 expression contributes to the epothilone response of mitotic cells. Br.J.Cancer 108 82. PMID: 23321512.

If you know of a relevant citation for this product please let us know.

Keywords: Epothilone B, supplier, Microtubule, stabilization, agent, promotes, tubulin, polymerization, G2-M, cell, cycle, arrest, Tau, Tubulin, Mitosis, EpothiloneB

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