Histamine dihydrochloride

Cat. No. 3545

Histamine dihydrochloride C5H9N3.2HCl [56-92-8]

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Chemical Name: 2-(4-Imidazolyl)ethylamine dihydrochloride

Biological Activity

Endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Hill et al (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 49 253. PMID: 9311023.

Maintz and Novak (2007) Histamine and histamine intolerance. Am.J.Clin.Nutr. 85 1185. PMID: 17490952.

Thurmond et al (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 7 41. PMID: 18172439.

If you know of a relevant citation for this product please let us know.

Keywords: Histamine dihydrochloride, supplier, Endogenous, histamine, receptor, agonists, H4, Receptors, Histamine, H1, H2, H3, histaminergic

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