Cat. No. 3498
Biological ActivityIntegrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Grigoriou et al (2005) Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. 280 1733. PMID: 15522882.
Droppelmann et al (2009) Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin. J.Biol.Chem. 284 13551. PMID: 19276073.
Moon et al (2009) Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir.Res. 10 18. PMID: 19272161.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: RGDS peptide, supplier, Integrin, binding, sequence, inhibits, inhibitors, Receptors, Adhesion, Molecules
Find multiple products by catalog number
New Products in this Area
Inhibitor of TNF-α receptor 1 signalingC34
TLR4 inhibitorBIRT 377
Potent negative allosteric modulator of LFA-1BTT 3033
Selective inhibitor of integrin α2β1
March 28 - April 1, 2015