R&D Systems Inc. Tocris Bioscience Boston Biochem

RGDS peptide

Cat. No. 3498

RGDS peptide Arg-Gly-Asp-Ser

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Biological Activity

Integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.

Technical Data

M.Wt:
433.42
Formula:
C15H27N7O8
Sequence:
RGDS
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
91037-65-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Grigoriou et al (2005) Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. 280 1733. PMID: 15522882.

Droppelmann et al (2009) Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin. J.Biol.Chem. 284 13551. PMID: 19276073.

Moon et al (2009) Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir.Res. 10 18. PMID: 19272161.

If you know of a relevant citation for this product please let us know.

Keywords: RGDS peptide, supplier, Integrin, binding, sequence, inhibits, inhibitors, Receptors, Adhesion, Molecules

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