SID 7969543Cat No. 3440 |
Price and Availability |
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Chemical Name: Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-ox oethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoat e |
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Biological Activity
Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM).Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Roth et al (2008) Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.Chem.Lett. 18 2628. Madoux et al (2008) Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 73 1776.If you know of a useful citation for this product please let us know.
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Keywords: SID 7969543, Selective, steroidogenic, factor-1, SF-1, NR5A1, inhibitors, Nuclear, Receptors, Steroidogenic, Factor-1, SID7969543
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