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SID 7969543

Cat No. 3440

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Chemical Name: Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-ox oethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoat e

Biological Activity

Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC₅₀ values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC₅₀ = 30 nM).

Technical Data

M.Wt:

452.46

Formula:

C₂₄H₂₄N₂O₇

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

[868224-64-0]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Roth et al (2008) Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.Chem.Lett. 18 2628. Madoux et al (2008) Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 73 1776.

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