SID 7969543

Cat No. 3440

SID 7969543 C24H24N2O7 [868224-64-0]

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Chemical Name: Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-ox oethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoat e

Biological Activity

Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM).

Technical Data

M.Wt:
452.46
Formula:
C24H24N2O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
[868224-64-0]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Roth et al (2008) Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.Chem.Lett. 18 2628. Madoux et al (2008) Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 73 1776.

View Related Products by Target

Keywords: SID 7969543, Selective, steroidogenic, factor-1, SF-1, NR5A1, inhibitors, Nuclear, Receptors, Steroidogenic, Factor-1, SID7969543,

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