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MCL 0020

Cat. No. 3438

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Biological Activity

Potent and selective melanocortin MC₄ receptor antagonist (IC₅₀ values are 11.63, 1115 and > 10 000 nM at MC₄, MC₃ and MC₁ receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.

Technical Data

M.Wt:

609.73

Formula:

C₃₄H₃₉N₇O₄

Sequence:

XRX

(Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide)

Solubility:

Soluble to 2 mg/ml in 20% acetonitrile

Storage:

Store at -20°C

CAS No:

475498-26-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95. PMID: 12909200.

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