Cat. No. 3438
Biological ActivityPotent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
(Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95. PMID: 12909200.
If you know of a relevant citation for this product please let us know.
Keywords: MCL 0020, supplier, Selective, MC4R, receptor, antagonists, Receptors, Melanocortin, MCL0020
Find multiple products by catalog number
New Products in this Area
Oxytocin analogML 221
Apelin receptor (APJ) antagonistQ94 hydrochloride
Negative allosteric modulator at PAR1 receptorFSLLRY-NH2
PAR2 peptide antagonistSB 611812
Urotensin-II (UT) antagonist; attenuates cardiac dysfunctionTC-MCH 7c
Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonistCYM 9484
Potent NPY Y2 receptor antagonist
Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.