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S 25585

Cat. No. 3432

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Chemical Name: 1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazine

Biological Activity

Potent neuropeptide Y (NPY) Y₅ receptor antagonist (IC₅₀ values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y₅, Y₁, Y₂ and Y₄ receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y₅ receptors.

Technical Data

M.Wt:

528.5

Formula:

C₂₂H₂₃F₃N₄O₆S

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at RT

CAS No:

263-849-50-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Della-Zuana et al (2004) A potent and selective NPY Y₅ antagonist reduces food intake but not through blockade of the NPY Y₅ receptor. Int.J.Obes. 28 628.

Beauverger et al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489. PMID: 15601626.

Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28 664.

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Keywords: S 25585, supplier, Potent, selective, NPY, Y5, antagonists, neuropeptide, Receptors, S25585, neuropeptides

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