S 25585Cat No. 3432 |
Price and Availability |
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Chemical Name: 1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)ph enyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazin e |
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Biological Activity
Potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Della-Zuana et al (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor. Int.J.Obes. 28 628. Beauverger et al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489. Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28 664.If you know of a useful citation for this product please let us know.
Keywords: S 25585, Potent, selective, NPY, Y5, antagonists, neuropeptide, Receptors, S25585
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