Cat. No. 3428
Alternative Name: Dimethyltryptamine
Chemical Name: N,N-Dimethyl-1H-indole-3-ethanamine
Biological ActivityEndogenous σ1 receptor ligand and psychoactive plant compound (Ki = 14.8 μM). Binding to σ1 inhibits voltage-gated Na+ channels and is responsible for the behavioral effects of DMT. Also a 5-HT2A receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (Ki = 4.0 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Cozzi et al (2009) Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transportere and the vesicle monoamine transporter. J.Neural Transm. 116 1591. PMID: 19756361.
Fontanilla et al (2009) The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 323 934. PMID: 19213917.
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Keywords: DMT, supplier, sigma, σ, sigma1, σ1, receptors, ligands, 5-HT2A, serotonin, agonists, SERT, transporters, 5-HT
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