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DMTCat. No. 3428 |
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Alternative Name: Dimethyltryptamine Chemical Name: N,N-Dimethyl-1H-indole-3-ethanamine |
Biological Activity
Endogenous σ1 receptor ligand and psychoactive plant compound (Ki = 14.8 μM). Binding to σ1 inhibits voltage-gated Na+ channels and is responsible for the behavioral effects of DMT. Also a 5-HT2A receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (Ki = 4.0 μM).Certificate of Analysis / Safety Data Sheet
References
Cozzi et al (2009) Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transportere and the vesicle monoamine transporter. J.Neural Transm. 116 1591. PMID: 19756361.
Fontanilla et al (2009) The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 323 934. PMID: 19213917.
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Keywords: DMT, supplier, sigma, σ, sigma1, σ1, receptors, ligands, 5-HT2A, serotonin, agonists, SERT, transporters, 5-HT
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