Cat. No. 3412
Alternative Name: 4-OH-TAM
Chemical Name: 4-[(1Z)-1-[4-[2-(Dimethylamino)etho
Biological ActivityEstrogen receptor antagonist. Tamoxifen (Cat. No. 0999) metabolite; exhibits greater potency than the parent compound. Chemotherapeutic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jordan et al (1977) A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J.Endocrinology 75 305. PMID: 591813.
Yu and Forman (2003) Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator. J.Org.Chem. 68 9489. PMID: 14629178.
Desta et al (2004) Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6. J.Pharm.Exp.Ther. 310 1062. PMID: 15159443.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: (Z)-4-Hydroxytamoxifen, supplier, estrogen, receptors, antagonists, ER, 4-hydroxy-TAM, antiestrogens, antioestrogens, SERM, selective, modulators
Find multiple products by catalog number
New Products in this Area
High affinity aryl hydrogen receptor (AhR) agonistML 179
Selective liver receptor homolog 1 (LRH1) inverse agonistAC 186
Potent and selective ERβ agonist; neuroprotectiveIsotretinoin
Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiationBTC
Selective estrogen receptor modulator (SERM)
July 4 - 9, 2015