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COG 133

Cat. No. 3405

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Alternative Name: apoE(133-149)

Biological Activity

Apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC₅₀ = 445 nM).

Technical Data

M.Wt:

2169.73

Formula:

C₉₇H₁₈₁N₃₇O₁₉

Sequence:

LRVRLASHLRKLRKRLL

(Modifications: Leu-1 = N-terminal Ac, Leu-17 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in 20% acetonitrile / water

Storage:

Store at -20°C

CAS No:

514200-66-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Gay et al (2006) Apolipoprotein E-derived peptides block α7 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 316 835. PMID: 16249370.

Li et al (2006) Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. J.Pharmacol.Exp.Ther. 318 956. PMID: 16740622.

Sheng et al (2008) N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein. Neuropharmacology 55 204. PMID: 18602124.

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Keywords: COG 133, supplier, apoE, peptide, fragment, α7, alpha7, a7, nAChR, antagonists, NMDA, Nicotinic, Receptors, Acetylcholine, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, COG133, apoE(133149), LDL, lipoprotein, apolipoproteins