Cat. No. 3395
Alternative Name: CEP-701
Chemical Name: (9S,10S,12R)-2,3,9,10,11,12-Hexahyd
Biological ActivityPotent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Miknyoczki et al (1999) The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness. Ann.N.Y.Acad.Sci. 880 252. PMID: 10415871.
Weisel et al (2007) Effect of FLT3 inhibition on normal hematopoietic progenitor cells. Ann.N.Y.Acad.Sci. 1106 190. PMID: 17442779.
Hexner et al (2008) Lestaurinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders. Blood 111 5663. PMID: 17984313.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Lestaurtinib, supplier, TrkA, JAK2, FLT3, inhibitors, Neurotrophin, Receptors, Tyrosine, Kinases, RTKs, Janus-Activated, CEP701, Tocris Bioscience, JAK Inhibitors
Find multiple products by catalog number
New Products in this Area
PKC activator; also NF-κB activatorTBCA
Selective CK2 inhibitorMSC 2032964A
Potent and selective ASK1 inhibitor; orally bioavailableCW 008
PKA signaling activator; promotes osteogenesis from hMSCsPF 06447475
Potent LRRK2 inhibitor; neuroprotectiveAMG PERK 44
Potent and selective PERK inhibitor; orally bioavailableCGP 60474
Potent dual cdk1/cdk2 inhibitorCGP 74514 dihydrochloride
Potent cdk1 inhibitorKG 5
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitorNilvadipine
Syk kinase inhibitor; inhibits Aβ productionCentrinone B
High affinity and selective PLK4 inhibitorHTH 01-015
Potent and selective NUAK1 inhibitorKobe 0065
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signalingOSU 03012
PDK1 inhibitor; inhibits Akt signalingSR 7826
Potent and selective LIMK inhibitor; antitumorMps BAY 2a
Potent and selective Mps1 kinase inhibitorNG 25
TGF-β-activated kinase (TAK1) inhibitorMI 14
Potent and selective PI 4-kinase IIIβ inhibitorCTA 056
ITK inhibitorAZD 1480
Potent and selective JAK2 inhibitor; antiangiogenicTC-S 7001
Potent and highly selective ROCK inhibitor; orally activeAS 2444697
Potent and selective IRAK4 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.