Lestaurtinib

Cat. No. 3395

Lestaurtinib C26H21N3O4 [111358-88-4]

Price and Availability

For Lestaurtinib pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: CEP-701

Chemical Name: (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one

Biological Activity

Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.

Technical Data

M.Wt:
439.46
Formula:
C26H21N3O4
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
111358-88-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Miknyoczki et al (1999) The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness. Ann.N.Y.Acad.Sci. 880 252. PMID: 10415871.

Weisel et al (2007) Effect of FLT3 inhibition on normal hematopoietic progenitor cells. Ann.N.Y.Acad.Sci. 1106 190. PMID: 17442779.

Hexner et al (2008) Lestaurinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders. Blood 111 5663. PMID: 17984313.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Lestaurtinib, supplier, TrkA, JAK2, FLT3, inhibitors, Neurotrophin, Receptors, Tyrosine, Kinases, RTKs, Janus-Activated, CEP701, Tocris Bioscience, JAK Inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

JAK-STAT Pathway

JAK-STAT Signaling Pathway

JAK-STAT signaling is involved in many fundamental cellular processes such as cell proliferation and hematopoiesis. View pathway or download PDF today.

divider line

New Products in this Area

Prostratin

PKC activator; also NF-κB activator

TBCA

Selective CK2 inhibitor

MSC 2032964A

Potent and selective ASK1 inhibitor; orally bioavailable

CW 008

PKA signaling activator; promotes osteogenesis from hMSCs

PF 06447475

Potent LRRK2 inhibitor; neuroprotective

AMG PERK 44

Potent and selective PERK inhibitor; orally bioavailable

CGP 60474

Potent dual cdk1/cdk2 inhibitor

CGP 74514 dihydrochloride

Potent cdk1 inhibitor

KG 5

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Nilvadipine

Syk kinase inhibitor; inhibits Aβ production

Centrinone B

High affinity and selective PLK4 inhibitor

HTH 01-015

Potent and selective NUAK1 inhibitor

Kobe 0065

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling

OSU 03012

PDK1 inhibitor; inhibits Akt signaling

SR 7826

Potent and selective LIMK inhibitor; antitumor

Mps BAY 2a

Potent and selective Mps1 kinase inhibitor

NG 25

TGF-β-activated kinase (TAK1) inhibitor

MI 14

Potent and selective PI 4-kinase IIIβ inhibitor

CTA 056

ITK inhibitor

AZD 1480

Potent and selective JAK2 inhibitor; antiangiogenic

TC-S 7001

Potent and highly selective ROCK inhibitor; orally active

AS 2444697

Potent and selective IRAK4 inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.