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CNQXCat. No. 0190 |
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Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione |
Biological Activity
Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex. CNQX disodium salt (Cat. No. 1045) also available.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Resources
Other Information
Certificate of Analysis / Safety Data Sheet
References
Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701. PMID: 2899909.
Long et al (1990) Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 100 850. PMID: 1976402.
Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25. PMID: 2155495.
King et al (1992) Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 107 375. PMID: 1358390.
If you know of a relevant citation for this product please let us know.
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Keywords: CNQX, supplier, Potent, AMPA/kainate, antagonists, NMDA, glycine, site, Glutamate, Kainate, Receptors, iGluR, Ionotropic, AMPA, N-Methyl-D-Aspartate
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