AnastrozoleCat No. 3388 |
Price and AvailabilitySpecial ConditionsNo more than 1 g per individual per year to be sold without prior permission from the license holder. |
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Alternative Name: Chemical Name: a1,a1,a3,a3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl) -1,3-benzenediacetonitrile |
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Biological Activity
Potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.Licensing Information
Sold for research purposes only under agreement from AstraZeneca.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Dukes et al (1996) The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 58 439. Goss and Tye (1997) Anastrozole: a new selective nonsteroidal aromatase inhibitor. Oncology 11 1697. Buzdar (2001) Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting? Br.J.Cancer 85 6.If you know of a useful citation for this product please let us know.
Keywords: Anastrozole, Potent, aromatase, CYP19, inhibitors, ERR, Estrogen, Receptors, Cytochrome, P450, AstraZeneca
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