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VU 152100Cat. No. 3383 |
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Chemical Name: 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide |
Biological Activity
Selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM). Induces 21-fold shift in ACh potency at M4 receptor. Displays no activity at other mAChR subtypes.Certificate of Analysis / Safety Data Sheet
References
Brady et al (2008) Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 327 941. PMID: 18772318.
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Keywords: VU 152100, supplier, muscarinic, receptors, mAChR, M4, acetylcholine, ACh, selective, positive, allosteric, modulators, VU152100
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