VU 152100

Cat No. 3383new product

VU 152100 C18H19N3O2S

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Chemical Name: 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]py ridine carboxamide

Biological Activity

Selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM). Induces 21-fold shift in ACh potency at M4 receptor. Displays no activity at other mAChR subtypes.

Technical Data

M.Wt:
341.43
Formula:
C18H19N3O2S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at RT

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Brady et al (2008) Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 327 941.

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Keywords: VU 152100, muscarinic, receptors, mAChR, M4, acetylcholine, ACh, selective, positive, allosteric, modulators

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