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Cortistatin 14

Cat. No. 3374

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Biological Activity

Endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst₁ - sst₅) and prevents somatostatin-14 binding (IC₅₀ values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst₁, sst₂, sst₃, sst₄ and sst₅ receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.

Technical Data

M.Wt:

1721.03

Formula:

C₈₁H₁₁₃N₁₉O₁₉S₂

Sequence:

PCKNFFWKTFSSCK

(Modifications: Disulfide bridge between 2 - 13)

Solubility:

Soluble to 0.70 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

193829-96-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157.

Spier and de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 33 228.

Deghenghi et al (2001) Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 24 RC1. PMID: 11227737.

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Keywords: Cortistatin 14, supplier, Endogenous, neuropeptide, binds, sst1, sst2, sst3, sst4, sst5, GHS-R1a, Receptors, Somatostatin, Growth, Hormone, Secretagogue, 1a, Ghrelin, Cortistatin14, neuropeptides

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