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AC 264613

Cat No. 3370

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Chemical Name: (±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide

Biological Activity

Potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca²⁺ mobilization and cellular proliferation in vitro (pEC₅₀ values are 6.9, 7.0 and 7.5 respectively).

Technical Data

M.Wt:

400.27

Formula:

C₁₉H₁₈BrN₃O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

[1051487-82-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Gardell et al (2008) Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 327 799. Seitzberg et al (2008) Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 51 5490.

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Keywords: AC 264613, Potent, selective, PAR2, agonists, receptors, protease-activated, proteinase-activated

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