Cat. No. 3364
Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazep
Biological ActivityGLP and G9a histone lysine methyltransferase inhibitor (IC50 values are 0.7 and 1.7 μM respectively) that displays no activity at other histone methyltransferases up to 37 μM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kubicek et al (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol.Cell 25 473. PMID: 17289593.
Shi et al (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3 568. PMID: 18983970.
Chang et al (2009) Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat.Struct.Mol.Biol. 16 312. PMID: 19219047.
Malmquist et al (2012) Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc.Natl.Acad.Sci.U S A 109 16708. PMID: 23011794.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: BIX 01294, supplier, G9a-like, protein, and, G9a, histone, lysine, methyltransferases, HMTases, inhibitors, BIX01294, stem, cells, epigenetics
Find multiple products by catalog number
New Products in this Area
N-acetyltransferase 10 (NAT10) inhibitorEPZ 004777
Highly potent DOT1L inhibitorOICR 9429
High affinity and selective WDR5 antagonistMM 102
WDR5/MLL interaction inhibitorUNC 2327
Allosteric inhibitor of PRMT3GSK 2194069
Potent human fatty acid synthase (hFAS) inhibitorFuramidine dihydrochloride
Selective PRMT1 inhibitorXY1
Negative control of SGC 707 (Cat. No. 5367)SGC 707
Potent and selective allosteric inhibitor of PRMT3
September 7 - 9, 2015