BIX 01294

Cat No. 3364

BIX 01294 C28H38N6O2.3HCl [935693-62-2]

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Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimetho xy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride

Biological Activity

G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 values are 0.7 and 1.7 μM respectively) that displays no activity at other HTMases up to 37 μM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.

Technical Data

M.Wt:
600.02
Formula:
C28H38N6O2.3HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
[935693-62-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Kubicek et al (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol.Cell 25 473. Shi et al (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stell Cell 3 568. Chang et al (2009) Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat.Struct.Mol.Biol. 16 312.

If you know of a useful citation for this product please let us know.

View Related Products by Target

Cellular ProcessesMethyltransferases
Stem CellsTransferases

Keywords: BIX 01294, G9a-like, protein, and, G9a, histone, lysine, methyltransferases, HMTases, inhibitors, , BIX01294, stem, cells

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