BIX 01294Cat No. 3364 |
Price and Availability |
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Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimetho xy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride |
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Biological Activity
G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 values are 0.7 and 1.7 μM respectively) that displays no activity at other HTMases up to 37 μM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Kubicek et al (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol.Cell 25 473. Shi et al (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stell Cell 3 568. Chang et al (2009) Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat.Struct.Mol.Biol. 16 312.If you know of a useful citation for this product please let us know.
Keywords: BIX 01294, G9a-like, protein, and, G9a, histone, lysine, methyltransferases, HMTases, inhibitors, , BIX01294, stem, cells
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