Cat. No. 3360
Alternative Name: DAPH
Chemical Name: 5,6-Bis(phenylamino)-1H-isoindole-1
Biological ActivitySelective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Buchdunger et al (1994) 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 91 2334. PMID: 8134396.
Blanchard et al (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 101 14326. PMID: 15388848.
Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 105 7159. PMID: 18480256.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: CGP 52411, supplier, abeta42, ab42, aβ42, fibers, fibres, fibrils, epidermal, growth, factors, receptors, EGFR, Alzheimers, disease, CGP52411, amyloidbeta, amyloidb, amyloidβ
Find multiple products by catalog number
New Products in this Area
Potent c-MET/ALK inhibitorAC 710
Potent and selective PDGFR family inhibitorSPP 86
Potent RET inhibitorSGX 523
Selective and potent c-MET kinase inhibitorNBI 31772
High affinity insulin-like growth factor-I binding protein IGFBP inhibitorAPcK 110
Highly potent HGF/c-MET inhibitor; also AT4 antagonistAEE 788
Potent EGFR and VEGFR inhibitorXL 184
Potent VEGFR inhibitor; also inhibits other RTKs
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.