Cat. No. 3360
Alternative Name: DAPH
Chemical Name: 5,6-Bis(phenylamino)-1H-isoindole-1
Biological ActivitySelective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Buchdunger et al (1994) 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 91 2334.
Blanchard et al (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 101 14326.
Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 105 7159.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: CGP 52411, supplier, abeta42, ab42, aβ42, fibers, fibres, fibrils, epidermal, growth, factors, receptors, EGFR, Alzheimers, disease, CGP52411
Find multiple products by catalog number
New Products in this Area
Potent PDGFR and VEGFR inhibitorNVP ADW 742
ATP-competitive inhibitor of IGF1RKRCA 0008
Potent Ack1 and ALK dual inhibitor; orally bioavailableDDR1-IN-1 dihydrochloride
Selective DDR1 inhibitorHNGF6A
Humanin analog; increases insulin sensitivityHNGF6A
Humanin analog; increases insulin sensitivityGSK 1838705
Potent and selective IR and IGF1R inhibitor; antitumorGSK 1838705
Potent and selective IR and IGF1R inhibitor; antitumorSUN 11602
Basic fibroblast growth factor (bFGF) mimetic; neuroprotectiveSUN 11602
Basic fibroblast growth factor (bFGF) mimetic; neuroprotective
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.