R&D Systems Inc. Tocris Bioscience Boston Biochem

AM 404

Cat. No. 1116

AM 404 C26H37NO2 [198022-70-7]

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Chemical Name: N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Biological Activity

Competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available in water soluble emulsion (Cat. No. 1685).

Technical Data

M.Wt:
395.58
Formula:
C26H37NO2
Solubility:
Soluble to 50 mM in ethanol and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
198022-70-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Beltramo et al (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094. PMID: 9262477.

Calignano et al (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM 404. Eur.J.Pharmacol. 337 R1. PMID: 9389389.

Piomelli et al (1999) Structural determinants for recognition and translocation by the anandamide transporter. Proc.Natl.Acad.Sci.U.S.A. 96 5802. PMID: 10318965.

Zygmunt et al (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396 39. PMID: 10822052.

If you know of a relevant citation for this product please let us know.

Keywords: AM 404, supplier, Vanilloid, receptors, agonists, anandamide, transport, inhibitors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, AMT, Transporters, Cannabinoids, Monoamine, Neurotransmitter, AM404

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