Cat. No. 1116
Chemical Name: N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-e
Biological ActivityCompetitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available in water soluble emulsion (Cat. No. 1685).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Beltramo et al (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094. PMID: 9262477.
Calignano et al (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM 404. Eur.J.Pharmacol. 337 R1. PMID: 9389389.
Piomelli et al (1999) Structural determinants for recognition and translocation by the anandamide transporter. Proc.Natl.Acad.Sci.U.S.A. 96 5802. PMID: 10318965.
Zygmunt et al (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396 39. PMID: 10822052.
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Keywords: AM 404, supplier, Vanilloid, receptors, agonists, anandamide, transport, inhibitors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, AMT, Transporters, Cannabinoids, Monoamine, Neurotransmitter, AM404