R&D Systems Inc. Tocris Bioscience Boston Biochem

AM 404

Cat. No. 1116

AM 404 C26H37NO2 [198022-70-7]

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Chemical Name: N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Biological Activity

Competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available in water soluble emulsion (Cat. No. 1685).

Technical Data

M.Wt:
395.58
Formula:
C26H37NO2
Solubility:
Soluble to 50 mM in ethanol and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
198022-70-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Beltramo et al (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094. PMID: 9262477.

Calignano et al (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM 404. Eur.J.Pharmacol. 337 R1. PMID: 9389389.

Piomelli et al (1999) Structural determinants for recognition and translocation by the anandamide transporter. Proc.Natl.Acad.Sci.U.S.A. 96 5802. PMID: 10318965.

Zygmunt et al (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396 39. PMID: 10822052.

If you know of a relevant citation for this product please let us know.

Keywords: AM 404, supplier, Vanilloid, receptors, agonists, anandamide, transport, inhibitors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, AMT, Transporters, Cannabinoids, Monoamine, Neurotransmitter, AM404

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