R&D Systems Inc. Tocris Bioscience Boston Biochem

10Panx

Cat. No. 3348

10Panx Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr

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Biological Activity

Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.

Technical Data

M.Wt:
1242.37
Formula:
C58H79N15O16
Sequence:
WRQAAFVDSY
Solubility:
Soluble to 1 mg/ml in 20mM PBS buffer with gentle warming
Storage:
Store at -20°C
CAS No:
955091-53-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor. EMBO J. 25 5071. PMID: 17036048.

Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112. PMID: 17652431.

Thompson et al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555. PMID: 19056988.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: 10Panx, supplier, Panx-1, mimetic, inhibitory, peptide, blocks, pannexin-1, gap, junctions, Connexins, Channels, modulators

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