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SNAP 94847 hydrochloride

Cat No. 3347

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Chemical Name: N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piper idinyl]-4-methylphenyl]-2-methylpropanamide hydrochloride

Biological Activity

Potent melanin-concentrating hormone receptor 1 (MCH₁) antagonist (K_i = 2.2 nM, K_D = 530 pM) that displays > 80-fold and > 500-fold selectivity over α_1A and D₂ receptors respectively. Increases neurogenesis in the dentate gyrus and decreases food-reinforced operant responding in vivo. Exhibits anxiolytic activity and is orally active.

Technical Data

M.Wt:

515.03

Formula:

C₂₉H₃₂F₂O₂.HCl

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

[487051-12-7]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Chen et al (2007) Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key features of HTS hits. J.Med.Chem. 50 3883. David et al (2007) Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J.Pharmacol.Exp.Ther. 321 237. Nair et al (2009) Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats. Psychopharmacology In press.

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Keywords: SNAP 94847 hydrochloride, Potent, selective, MCH1, antagonists, Melanin-concentrating, Hormone, Receptors, SNAP94847, hydrochloride

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