ARL 17477 dihydrochloride
Cat. No. 3319
Chemical Name: N-[4-[2-[[(3-Chlorophenyl)methyl]am
Biological ActivitySelective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC50 values are 1 and 17 μM for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Zhang et al (1996) ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J.Cereb.Flow Metab. 16 599.
Hicks et al (1999) Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia. Eur.J.Pharmacol. 381 113. PMID: 10554878.
O'Neill et al (2000) ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res. 871 234. PMID: 10899290.
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Keywords: ARL 17477 dihydrochloride, supplier, neuronal, nitric, oxide, synthase, nNOS, inhibitors, ARL17477
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