R&D Systems Inc. Tocris Bioscience Boston Biochem

Fluvastatin sodium

Cat. No. 3309

Fluvastatin sodium C24H25FNNaO4 [93957-55-2]

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Chemical Name: (±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt

Biological Activity

Orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.

Technical Data

M.Wt:
433.45
Formula:
C24H25FNNaO4
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
93957-55-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Dansette et al (2000) HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp.Toxicol.Pathol. 52 145. PMID: 10965989.

Yamamoto et al (2001) Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. J.Pharm.Pharmacol. 53 227. PMID: 11273020.

Turner et al (2007) Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458. PMID: 18049315.

If you know of a relevant citation for this product please let us know.

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Keywords: Fluvastatin sodium, supplier, HMG-CoA, reductases, inhibitors

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