Fluvastatin sodium

Cat. No. 3309

Fluvastatin sodium C24H25FNNaO4 [93957-55-2]

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Chemical Name: (±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt

Biological Activity

Orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.

Technical Data

Soluble to 25 mM in water and to 100 mM in DMSO
>98 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Dansette et al (2000) HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp.Toxicol.Pathol. 52 145. PMID: 10965989.

Yamamoto et al (2001) Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. J.Pharm.Pharmacol. 53 227. PMID: 11273020.

Turner et al (2007) Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458. PMID: 18049315.

If you know of a relevant citation for this product please let us know.

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Keywords: Fluvastatin sodium, supplier, HMG-CoA, reductases, inhibitors

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