PF 750

Cat. No. 3307

PF 750 C22H23N3O [959151-50-9]

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Chemical Name: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide

Biological Activity

Irreversible fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 16.2 nM) that displays no activity at a range of other serine hydrolases. Selectively inhibits FAAH within the central nervous system. Orally active.

Technical Data

M.Wt:
345.44
Formula:
C22H23N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
959151-50-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Ahn et al (2007) Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46 13019. PMID: 17949010.

Mileni et al (2008) Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc.Natl.Acad.Sci.USA 105 12820.

If you know of a relevant citation for this product please let us know.

Keywords: PF 750, supplier, Selective, FAAH, inhibitors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PF750

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