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PF 750

Cat. No. 3307

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Chemical Name: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide

Biological Activity

Irreversible fatty acid amide hydrolase (FAAH) inhibitor (IC₅₀ = 16.2 nM) that displays no activity at a range of other serine hydrolases. Selectively inhibits FAAH within the central nervous system. Orally active.

Technical Data

M.Wt:

345.44

Formula:

C₂₂H₂₃N₃O

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at RT

CAS No:

959151-50-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Ahn et al (2007) Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46 13019. PMID: 17949010.

Mileni et al (2008) Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc.Natl.Acad.Sci.USA 105 12820.

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