Cat. No. 1231
Chemical Name: 1,6,7,8,9,11aβ,12,13,14,14αa-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent(f)oxacyclotridecin-4-one
Biological ActivityReversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Ktistakis et al (1992) Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein. Nature 356 344. PMID: 1549178.
Tsai et al (1994) Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain. Proc.Natl.Acad.Sci.U.S.A. 91 3063. PMID: 8159707.
Morinaga et al (1996) Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF)1 and ARF3 that contains a Sec7-like domain. Proc.Natl.Acad.Sci.U.S.A. 93 12856. PMID: 8917509.
Ding et al (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 282 4702. PMID: 17135238.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Brefeldin A, supplier, Disrupts, protein, translocation, Golgi, ADP-ribosylation, factor, BrefeldinA
Find multiple products by catalog number
New Products in this Area
Inhibits Hedgehog signalingJervine
Inhibitor of Hedgehog (Hh) signaling; binds directly to SmoGue 1654
Selective inhibitor of OXE-R Gβγ signaling
Win a Kindle
May 21 - 24, 2013
Booth Number: 32