Cat. No. 0875
Chemical Name: 1-(3-Chlorophenyl)piperazine hydrochloride
Biological Activity5-HT2C/2B receptor agonist/partial agonist; displays some activity at 5-HT2A and 5-HT1 receptors. pEC50 values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Suppresses locomotor activity in rats in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Lucki et al (1989) Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. J.Pharmacol.Exp.Ther. 249 155. PMID: 2709329.
Curzon et al (1990) m-CPP: a tool for studying behavioural responses associated with 5-HT1C receptors. TiPS 11 181. PMID: 2188399.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165.
Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13. PMID: 10498829.
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Keywords: m-CPP hydrochloride, supplier, 5-HT2B/2C, receptor, agonists, Serotonin, 5-HT2C, Receptors, 5-HT2B
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