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m-CPP hydrochloride

Cat. No. 0875

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Chemical Name: 1-(3-Chlorophenyl)piperazine hydrochloride

Biological Activity

5-HT_2C/2B receptor agonist/partial agonist; displays some activity at 5-HT_2A and 5-HT₁ receptors. pEC₅₀ values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT_2C, _2B and _2A, bovine 5-HT_1A and rat 5-HT_1B receptors respectively. Suppresses locomotor activity in rats in vivo.

Technical Data

M.Wt:

233.14

Formula:

C₁₀H₁₃ClN₂.HCl

Solubility:

Soluble to 100 mM in water

Purity:

>99 %

Storage:

Store at RT

CAS No:

65369-76-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Lucki et al (1989) Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. J.Pharmacol.Exp.Ther. 249 155. PMID: 2709329.

Curzon et al (1990) m-CPP: a tool for studying behavioural responses associated with 5-HT_1C receptors. TiPS 11 181. PMID: 2188399.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165.

Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT_2A, 5-HT_2B and 5-HT_2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13. PMID: 10498829.

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