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UVI 3003

Cat No. 3303

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Chemical Name: 3-[4-Hydroxy-3-[5,6,7,8-tetrahtdro-5,5,8,8-tetramethyl- 3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid

Biological Activity

RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.

Technical Data

M.Wt:

436.58

Formula:

C₂₈H₃₆O₄

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

[847239-17-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Nahoum et al (2007) Modulators of the stuctural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci. 104 17323. Le Maire et al (2009) Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO Rep. 10 367. Santin et al (2009) Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. J.Med.Chem. 52 3150.

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