FinasterideCat No. 3293 |
Price and Availability |
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Alternative Name: MK 906 Chemical Name: (5a,17b)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene -17-carboxamide |
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Biological Activity
Antiandrogen that inhibits type II 5α reductase (IC50 = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo. Orally active.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Thigpen and Russell (1992) Four-amino acid segment in steroid 5a-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. J.Biol.Chem. 267 8577. Gao et al (2004) Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5a-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 145 5420. Mukai et al (2008) Studies on neurosteroids XXV. Influence of a 5a-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Biol.Pharm.Bull. 31 1646.If you know of a useful citation for this product please let us know.
Keywords: Finasteride, Type, II, 5α-reductases, 5alpha-reductases, inhibitors, MK906
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