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YM 511Cat No. 3278 |
Price and Availability |
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Chemical Name: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]b enzonitrile |
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Biological Activity
Orally active, potent aromatase (CYP19) inhibitor (IC50 values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM).Licensing Information
(Sold with the permission of Astellas Pharma Inc.)Technical Data
M.Wt:354.2
Formula:C16H12BrN5
Solubility:Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity: >99 %
Storage:Store at RT
CAS No:[148869-05-0]
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch
References
Kudoh et al (1995) The potent and selective inhibiton of estrogen production by non-steroidal aromatase inhibitor, YM511. J.Steroid Biochem.Molec.Biol. 54 265. Kudoh et al (1996) Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell. J.Steroid Biochem.Molec.Biol. 58 189. Okada et al (1996) Studies on aromatase inhibitors I. Synthesis and biological evaulation of 4-amino-4H-1,2,4-triaole derivatives. Chem.Pharm.Bull. 44 1871.If you know of a useful citation for this product please let us know.
Keywords: YM 511, Potent, aromatase, CYP19, inhibitors, Cytochrome, P450, ERR, Estrogen, Receptors, YM511
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