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Gemcitabine hydrochloride

Cat No. 3259

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Chemical Name: (+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride

Biological Activity

Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo.

Technical Data

M.Wt:

299.66

Formula:

C₉H₁₁F₂N₃O₄.HCl

Solubility:

Soluble to 100 mM in water and to 50 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

[122111-03-9]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Hertel et al (1990) Evaluation of the antitumor activity of Gemcitabine (2',2'-Difluoro-2'-deoxycytidine). Cancer Res. 50 4417. Heinemann et al (1995) Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism. Semin.Oncol. 22 Suppl.11 11. Plunkett et al (1995) Preclinical characteristics of gemcitabine. Anticancer Drugs 6 Suppl.6 7.

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