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Triptolide

Cat No. 3253

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Chemical Name: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b ,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethy l)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H )-one

Biological Activity

Inhibits cytokine-induced gene expression via inhibition of NF-κB transcriptional activity. Induces apoptosis in tumor cells by blocking TNF-α mediated c-IAP2 and c-IAP1 (members of the inhibitor of apoptosis family) induction. Immunosuppressive with anti-inflammatory and antitumor activity.

Technical Data

M.Wt:

360.4

Formula:

C₂₀H₂₄O₆

Solubility:

Soluble to 50 mM in DMSO

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

[38748-32-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Qui et al (1999) Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation. J.Biol.Chem. 274 13443. Lee et al (1999) PG490 (Triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells. J.Biol.Chem. 274 13451. Liacini et al (2005) Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes. Biochem.Biophys.Res.Comm. 327 320.

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Keywords: Triptolide, Blocks, TNF-α, TNF-alpha-mediated, c-IAP2, c-IAP1, induction, inhibitors, apoptosis, TNF-α, TNF-alpha-induced, NF-κB, NF-kappaB, NF-kB, activation, X-Linked, Apoptosis, XIAP, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors