Cat. No. 0759
Chemical Name: [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol
Biological ActivityPotent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Saul et al (1984) Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases. Arch.Biochem.Biophys. 230 668. PMID: 6424575.
Gruters et al (1987) Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 330 74. PMID: 2959866.
Welker et al (1987) Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc.Natl.Acad.Sci.U.S.A. 84 8120. PMID: 2825177.
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Keywords: Castanospermine, supplier, β-glucosidases, beta-glucosidases, b-glucosidase, inhibitors, a-Glucosidase, α-glucosidase, alpha-glucosidase, Glycosylases, Carbohydrate, Metabolism
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