R&D Systems Inc. Tocris Bioscience Boston Biochem

Castanospermine

Cat. No. 0759

Castanospermine C8H15NO4 [79831-76-8]

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Chemical Name: [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol

Biological Activity

Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

Technical Data

M.Wt:
189.21
Formula:
C8H15NO4
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in water
Storage:
Store at RT
CAS No:
79831-76-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Saul et al (1984) Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases. Arch.Biochem.Biophys. 230 668. PMID: 6424575.

Gruters et al (1987) Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 330 74. PMID: 2959866.

Welker et al (1987) Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc.Natl.Acad.Sci.U.S.A. 84 8120. PMID: 2825177.

If you know of a relevant citation for this product please let us know.

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Keywords: Castanospermine, supplier, β-glucosidases, beta-glucosidases, b-glucosidase, inhibitors, a-Glucosidase, α-glucosidase, alpha-glucosidase, Glycosylases, Carbohydrate, Metabolism

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