R&D Systems Inc. Tocris Bioscience Boston Biochem

[Phe8Ψ(CH-NH)-Arg9]-Bradykinin

Cat. No. 3229

[Phe8Y(CH-NH)Arg9]-Bradykinin Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Ψ(CH2-NH)-Arg

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Biological Activity

Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin (Cat No. 3004) in vivo.

Technical Data

M.Wt:
1046.23
Formula:
C50H75N15O10
Sequence:
RPPGFSPFR

(Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH2-NH))

Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Desiccate at -20°C
CAS No:
118122-39-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Drapeau et al (1988) [Phe8Ψ(CH2-NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down by either kininase I or kininase II. Eur.J.Pharmacol. 155 193. PMID: 2907489.

Marceau et al (2002) Kinin receptors: functional aspects. Int.Immunopharmacol. 2 1729. PMID: 12489786.

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27. PMID: 15734727.

If you know of a relevant citation for this product please let us know.

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Keywords: [Phe8Y(CH-NH)Arg9]-Bradykinin, supplier, Selective, B2, agonists, Bradykinin, Receptors, [Phe8psi(CH-NH)Arg9]-Bradykinin

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