[Phe8Ψ(CH-NH)-Arg9]-Bradykinin

Cat. No. 3229

[Phe8Y(CH-NH)Arg9]-Bradykinin Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Ψ(CH2-NH)-Arg

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Biological Activity

Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin (Cat No. 3004) in vivo.

Technical Data

M.Wt:
1046.23
Formula:
C50H75N15O10
Sequence:
RPPGFSPFR

(Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH2-NH))

Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Desiccate at -20°C
CAS No:
118122-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Drapeau et al (1988) [Phe8Ψ(CH2-NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down by either kininase I or kininase II. Eur.J.Pharmacol. 155 193. PMID: 2907489.

Marceau et al (2002) Kinin receptors: functional aspects. Int.Immunopharmacol. 2 1729. PMID: 12489786.

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27. PMID: 15734727.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: [Phe8Y(CH-NH)Arg9]-Bradykinin, supplier, Selective, B2, agonists, Bradykinin, Receptors, [Phe8psi(CH-NH)Arg9]-Bradykinin

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