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[Phe⁸Ψ(CH-NH)-Arg⁹]-Bradykinin

Cat. No. 3229

[Phe8Y(CH-NH)Arg9]-Bradykinin Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Ψ(CH2-NH)-Arg

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Biological Activity

Selective bradykinin B₂ receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin (Cat No. 3004) in vivo.

Technical Data

M.Wt:

1046.23

Formula:

C₅₀H₇₅N₁₅O₁₀

Sequence:

RPPGFSPFR

(Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH₂-NH))

Solubility:

Soluble to 1 mg/ml in 20% acetonitrile / water

Storage:

Desiccate at -20°C

CAS No:

118122-39-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Drapeau et al (1988) [Phe⁸Ψ(CH₂-NH)Arg⁹]bradykinin, a B₂ receptor selective agonist which is not broken down by either kininase I or kininase II. Eur.J.Pharmacol. 155 193. PMID: 2907489.

Marceau et al (2002) Kinin receptors: functional aspects. Int.Immunopharmacol. 2 1729. PMID: 12489786.

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27. PMID: 15734727.

If you know of a relevant citation for this product please let us know.

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Keywords: [Phe8Y(CH-NH)Arg9]-Bradykinin, supplier, Selective, B2, agonists, Bradykinin, Receptors, [Phe8psi(CH-NH)Arg9]-Bradykinin

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