Cat. No. 3229
Biological ActivitySelective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin (Cat No. 3004) in vivo.
(Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH2-NH))
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Drapeau et al (1988) [Phe8Ψ(CH2-NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down by either kininase I or kininase II. Eur.J.Pharmacol. 155 193. PMID: 2907489.
Marceau et al (2002) Kinin receptors: functional aspects. Int.Immunopharmacol. 2 1729. PMID: 12489786.
Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27. PMID: 15734727.
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Keywords: [Phe8Y(CH-NH)Arg9]-Bradykinin, supplier, Selective, B2, agonists, Bradykinin, Receptors, [Phe8psi(CH-NH)Arg9]-Bradykinin
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January 12, 2016