Cat. No. 3226
Biological ActivityPotent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.
(Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Gobeil et al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833. PMID: 8901831.
Gobeil et al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33 823.
Duka et al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021. PMID: 14557281.
If you know of a relevant citation for this product please let us know.
Keywords: R 892, supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R892
Find multiple products by catalog number
New Products in this Area
High affinity ghrelin receptor agonistUrantide
Selective and competitive urotensin II antagonistML 154
Potent neuropeptide S receptor (NPSR) antagonistTC OT 39
Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonistTolvaptan
Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally activeML 00253764 hydrochloride
Melanocortin MC4 receptor antagonist; brain penetrantGSK 1562590 hydrochloride
High affinity, selective urotensin II (UT) receptor antagonist
November 15 - 19, 2014
Washington D.C., USA