Cat. No. 3226
Biological ActivityPotent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.
(Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Gobeil et al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833. PMID: 8901831.
Gobeil et al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33 823.
Duka et al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021. PMID: 14557281.
If you know of a relevant citation for this product please let us know.
Keywords: R 892, supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R892
Find multiple products by catalog number
New Products in this Area
Selective motilin receptor antagonistAdipoRon hydrochloride
Orally active AdipoR1 and AdipoR2 agonist; antidiabeticPG 931
Potent and selective MC4 receptor agonistCYM 50769
Novel non-peptide NPBWR1 antagonistPramlintide
Synthetic version of amylin (Cat. No. 3418)
June 30 - July 2, 2014
Booth Number: 39