R&D Systems Inc. Tocris Bioscience Boston Biochem

R 892

Cat. No. 3226

R 892 Ac-Lys-Arg-Pro-Pro-Gly-(αmethyl)Phe-Ser-DβNal-Ile

Price and Availability

For R 892 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.

Technical Data

M.Wt:
1154.37
Formula:
C58H83N13O12
Sequence:
KRPPGFSXI

(Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
229030-05-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Gobeil et al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833. PMID: 8901831.

Gobeil et al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33 823.

Duka et al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021. PMID: 14557281.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: R 892, supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R892

Quick Order

Find multiple products by catalog number

divider line

Peptide Hormone Receptors Product Listing

Peptide Hormone Receptor Product Listing

Highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Poster

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity.

divider line

New Product Guide

NPG

Highlights 150 new products added in the second half of 2014. View PDF today.

divider line

New Products in this Area

ML 354

Selective PAR4 antagonist

GW 438014A

NPY Y5 receptor antagonist

TC-FPR 43

Potent FPR2 agonist

TC-G 1003

High affinity somatostatin sst2 receptor agonist

Kisspeptin 10 (dog)

Endogenous ligand for canine kisspeptin receptor

MK 0677

High affinity ghrelin receptor agonist

Urantide

Selective and competitive urotensin II receptor antagonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.