R&D Systems Inc. Tocris Bioscience Boston Biochem

R 892

Cat. No. 3226

R 892 Ac-Lys-Arg-Pro-Pro-Gly-(αmethyl)Phe-Ser-DβNal-Ile

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Biological Activity

Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.

Technical Data

M.Wt:
1154.37
Formula:
C58H83N13O12
Sequence:
KRPPGFSXI

(Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
229030-05-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Gobeil et al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833. PMID: 8901831.

Gobeil et al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33 823.

Duka et al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021. PMID: 14557281.

If you know of a relevant citation for this product please let us know.

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Keywords: R 892, supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R892

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