Kifunensine

Cat. No. 3207

Kifunensine C8H12N2O6 [109944-15-2]

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Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione

Biological Activity

Inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.

Technical Data

M.Wt:
232.19
Formula:
C8H12N2O6
Solubility:
Soluble to 10 mM in water with sonication
Storage:
Store at -20°C
CAS No:
109944-15-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Elbein et al (1990) Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem. 265 1559.

Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892. PMID: 16292820.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Kifunensine, supplier, inhibitors, class, I, α-mannosidase, alpha-mannosidases, Glycosylases, Carbohydrate, Metabolism

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