Cat. No. 3207
Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-t
Biological ActivityInhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Elbein et al (1990) Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem. 265 1559.
Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892. PMID: 16292820.
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Keywords: Kifunensine, supplier, inhibitors, class, I, α-mannosidase, alpha-mannosidases, Glycosylases, Carbohydrate, Metabolism
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April 12 - 15, 2015