R&D Systems Inc. Tocris Bioscience Boston Biochem

Kifunensine

Cat. No. 3207

Kifunensine C8H12N2O6 [109944-15-2]

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Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione

Biological Activity

Inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.

Technical Data

M.Wt:
232.19
Formula:
C8H12N2O6
Solubility:
Soluble to 50 mM in water with gentle warming
Storage:
Store at -20°C
CAS No:
109944-15-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Elbein et al (1990) Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem. 265 1559.

Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892. PMID: 16292820.

If you know of a relevant citation for this product please let us know.

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Keywords: Kifunensine, supplier, inhibitors, class, I, α-mannosidase, alpha-mannosidases, Glycosylases, Carbohydrate, Metabolism

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